New Studies on Preventing Alzheimer’s

The Alzheimer’s Association estimates that one in eight people over age sixty-five has this disease and that the number will triple by 2050 to 16 million people. This would take a huge toll on our health care system, as well as on each family that would be burdened financially and emotionally dealing with their loved one. All of us, especially those approaching their “golden years,” want to do everything possible to avoid this fate.

Two new studies offer simple ways to prevent or treat what is called cognitive impairment, mild to moderate memory problems that can be early signs of dementia. The first study assigned participants with early memory impairment to either listen to music or to meditate for 12 minutes each day for three months. At the end of that time, both groups showed significant improvements in tests measuring memory and thinking ability. These gains were maintained or improved after another three months. Easy to do, cost-effective, and without side effects, these are activities that most of us can do on our own. (Journal of Alzheimer’s Disease, January 18, 2017)

You probably know that keeping active mentally is one way to prevent dementia. A recently-published study followed elderly people (ages 74-82) for four years to see how various activities affected their memory and thinking ability. Out of the 1929 people who were mentally normal at the beginning of the study, 456 developed cognitive impairment. Those who reported playing games, doing crafts, using a computer, or participating in social activities 1-2 times a week had a significantly lower risk of developing this problem than those who did them only 2-3 times a month. My bridge partner will be happy to hear this. (JAMA Neurology, January 30, 2017)

Finally, a provocative new study suggests that those people who develop high blood pressure late in life—age 80 or beyond—have a significantly lower risk of dementia. This is compatible with several other studies that found more cognitive impairment in seniors with a systolic blood pressure (the top number) below 130 and better mental functioning in those with values above 160. The authors of the new study theorize that higher blood pressure is needed in the elderly to force adequate blood flow to the brain due to age-associated hardening of the arteries. (Alzheimers Dement, January 17, 2017) On the other hand, high blood pressure earlier in life is thought to contribute to dementia, due to damage of the arteries leading to the brain.

There is also research linking many common drugs—statins, acid-reflux drugs, anti-histamines, tranquilizers, anti-depressants—with mental impairment and dementia. More about that in my book, coming June, 2018.

Disturbing News about Acid Reflux Drugs

A new study, reported at the November 2016 meeting of the American Heart Association, revealed a 20% increased risk of stroke in people taking proton-pump inhibitors (PPIs). This is on top of another study which found twice the risk of death from heart disease in people taking them. This is disturbing news, since experts estimate that seven out of ten people taking PPIs do not need them.

Proton-pump inhibitors are prescribed for acid reflux, also called GERD, and include Prilosec, Prevacid, and Nexium. They are blockbuster drugs, earning $13 billion each year in the US alone. While the approval of PPIs by the FDA was based on people taking them for only two weeks, many take them for years. Other dangerous side effects of PPIs include:

  • Vitamin D deficiency
  • Diarrhea infections
  • Pneumonia
  • Bone Fractures
  • Dementia
  • Kidney disease

Most of these side effects are because PPIs suppress the production of stomach acid, which you need to absorb important vitamins and minerals, such as calcium. PPIs also can destroy friendly bacteria in your stomach, paving the way for infections. The irony is that the vast majority of cases of acid reflux are not because of excess stomach acid. It is caused by weakness of a muscle that lets acid back up into the esophagus from the stomach.

There are several simple things that you can do to reduce acid reflux:

  • Lose five to ten pounds
  • Avoid tight clothing around the waist
  • Avoid certain foods—garlic, onion, tomato sauce, fatty and fried foods, caffeine
  • Eat several small meals throughout the day and wait 2-3 hours after dinner before going to bed
  • Elevate the head of your bed to help gravity keep food in your stomach

Unfortunately, if you are taking a PPI, it is very difficult to stop. This is because of a phenomenon known as rebound hyperacidity, whereby stomach acid actually increases after stopping a PPI. Tapering off these medications gradually and taking a simple antacid, such as Tums, Maalox, or Di-Gel, will help you to manage symptoms until your stomach acid returns to normal. Also, there are natural alternatives for acid reflux that you can use:

  • High-fiber foods, digestive enzymes, and probiotics
  • Aloe vera juice, licorice, apple cider vinegar, and slippery elm
  • Acupuncture and Chinese herbs
  • Stress reduction tapes, meditation, exercise

If your doctor has prescribed a PPI, talk to her about stopping it. The risk of serious side effects greatly outweighs its usefulness.

The study on PPIs and stroke can be found at: http://circ.ahajournals.org/content/134/Suppl_1/A18462. References for other studies on PPIs can be found in my book to be published in April.